Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- TBI
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Preclinical/no trial
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- 8-OH-DPAT; [3H]-8-OH-DPAT
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseTBIUnspecifiedMaleIntracerebroventricularSubthreshold dose, value not statedAfter injury induction
Model: Mild traumatic brain injury
Mild traumatic brain injury increased depression-like behaviour, which was reduced by a subthreshold dose of the 5-HT1A agonist 8-OH-DPAT and worsened by the antagonist WAY-100635.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
RatTBIControlled cortical impactHarlan Sprague-DawleyMalen = 64 rats in total; four injured groups of n=10 to 12 and fou…Intraperitoneal8-OH-DPAT 0.5 mg/kg; WAY 100635 0.5 mg/kg; SB 269970 HCl 2.…8-OH-DPAT 15 min after injury; antagonists immediately before injury, that is 1…
Model: Controlled cortical impact to the exposed right cortex, 2.8 mm depth at 4 m/s, under isoflurane anaesthesia after craniectomy; shams underwent identical surgery without impact
8-OH-DPAT alone, and combined with WAY 100635, improved Morris water maze acquisition relative to vehicle, and 8-OH-DPAT alone improved probe retention at 35.1 plus or minus 1.1 per cent versus 24.6 plus or minus 2.6 per cent. Co-administration with the 5-HT7 antagonist SB 269970 HCl abolished the…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
