4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis.
RatChemical/toxinSprague-DawleyMalen = 24 rats in three groupsIntraperitoneal50 mg/kg body weightPretreatment, for 3 days before modelling
Model: Severe acute pancreatitis induced by retrograde injection of 5% sodium taurocholate into the biliopancreatic duct
4-Phenylbutyric acid reduced pancreatic and intestinal injury, inflammatory cytokines, barrier markers and endoplasmic reticulum stress-driven epithelial apoptosis, although amylase, lipase, caspase-8 and caspase-9 changed only slightly.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.