PEDF-derived peptide promotes tendon regeneration through its mitogenic effect on tendon stem/progenitor cells.
RabbitOtherSprague-Dawley rats; New Zealand White rabbits for tendon cell isolationMale (rats)n = 16 rats randomised to peptide gel or vehicle, with 16 repai…Peri-lesional subcutaneous injection of the loaded gel150 microlitres of alginate gel containing 100 microM 29-merImmediately after injury
Model: Achilles tendon injury created by full-thickness insertion of an 18-gauge needle 1 cm proximal to the calcaneum
The 29-mer expanded resident tendon stem and progenitor cells, produced more organised collagen and raised ultimate tensile stress and Young modulus to about 89% of intact tendon compared with 69% and 61% for vehicle.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.