THERAPY DOSSIER · th-cd1ba8d2cbbe

Pigment epithelium-derived factor short peptide (29-mer) in alginate gel

Biologic · No ChEMBL entity for the PEDF 29-mer. ClinicalTrials.gov searched: all 8 PEDF records are observational or biomarker studies measuring endogenous PEDF (aqueous humour, vitreous, plasma, skin); no interventional trial administers PEDF or a PEDF-derived peptide as a therapy. Deliberate zero.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: No ChEMBL entity for the PEDF 29-mer. ClinicalTrials.gov searched: all 8 PEDF records are observational or biomarker studies measuring endogenous PEDF (aqueous humour, vitreous, plasma, skin); no interventional trial administers PEDF or a PEDF-derived peptide as a therapy. Deliberate zero.
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30606221 ↗2019Reported benefit

PEDF-derived peptide promotes tendon regeneration through its mitogenic effect on tendon stem/progenitor cells.

RabbitOtherSprague-Dawley rats; New Zealand White rabbits for tendon cell isolationMale (rats)n = 16 rats randomised to peptide gel or vehicle, with 16 repai…Peri-lesional subcutaneous injection of the loaded gel150 microlitres of alginate gel containing 100 microM 29-merImmediately after injury

Model: Achilles tendon injury created by full-thickness insertion of an 18-gauge needle 1 cm proximal to the calcaneum

The 29-mer expanded resident tendon stem and progenitor cells, produced more organised collagen and raised ultimate tensile stress and Young modulus to about 89% of intact tendon compared with 69% and 61% for vehicle.

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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Pigment epithelium-derived factor short peptide (29-mer) in alginate gel