Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice.
MouseChemical/toxinKunmingMalen = Four groups of 8 animals eachNot explicitly stated; administered as a suspension in 0.05% CMC-Na, oral administration implied50 and 100 mg/kg per dayPretreatment for 7 days, with acetaminophen given 1 h after the last dose
Model: Acetaminophen-induced acute liver injury, 350 mg/kg intraperitoneally
Baicalein pretreatment dose-dependently lowered transaminases, necrosis, malondialdehyde and inflammatory cytokines while restoring antioxidant enzymes and normalising autophagy and MAPK and JAK2/STAT3 signalling.
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