Phase IIa trial of Baicalein Tablets in healthy adults with influenza fever
Influenza
Enrolment: 180 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Influenza
Enrolment: 180 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Acetaminophen-induced acute liver injury, 350 mg/kg intraperitoneally
Baicalein pretreatment dose-dependently lowered transaminases, necrosis, malondialdehyde and inflammatory cytokines while restoring antioxidant enzymes and normalising autophagy and MAPK and JAK2/STAT3 signalling.
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Model: Carbon tetrachloride-induced acute liver injury and acute liver failure
Baicalein given orally after carbon tetrachloride conferred a survival benefit, raised hepatic IL-6 and TNF-alpha within 12 hours and lowered them at 24, 48 and 72 hours relative to control. TGF-alpha, HGF and EGF expression increased markedly at all time points, consistent with accelerated liver r…
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.