Thrombin contributes to the injury development and neurological deficit after acute subdural hemorrhage in rats only in collaboration with additional blood-derived factors.
RatHaemorrhage/shockUnspecifiedSprague-DawleyMalen = 65 rats randomised, 59 analysed after 6 exclusions; group s…Argatroban mixed into the subdural blood infusate; SCH79797 intracerebroventricularArgatroban 600 micrograms mixed into the 300 microlitre blo…At the time of haematoma formation; SCH79797 immediately before injury induction
Model: Acute subdural haemorrhage produced by subdural infusion of 300 microlitres of autologous venous blood at 50 microlitres per minute
Neither local thrombin inhibition nor PAR1 blockade significantly reduced 14-day lesion volume or neurological deficit, showing only non-significant trends towards benefit.
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