Tranexamic acid suppresses the release of mitochondrial DAMPs and reduces lung inflammation in a murine burn model.
MouseBurnScaldC57BL/6Malen = 4 to 5 animals per group, experiments performed in triplica…Tranexamic acid intraperitoneal; SB202190 topical to the burn woundTranexamic acid 100 mg/kg at 25 mg/mL; SB202190 1 mM topica…Immediately after the burn
Model: 40% total body surface area full-thickness scald burn, 80 degrees C water for 30 s, with intraperitoneal lactated Ringer resuscitation
Tranexamic acid and the topical p38 MAPK inhibitor each reduced circulating mitochondrial DNA and lung macrophage infiltration at 5 h, but neither reduced syndecan-1 shedding and their combination gave no additional benefit.
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