4-Phenylbutyrate Ameliorates Anxiety Disorder by Inhibiting Endoplasmic Reticulum Stress after Diffuse Axonal Injury.

4-Phenylbutyrate Ameliorates Anxiety Disorder by Inhibiting Endoplasmic Reticulum Stress after Diffuse Axonal Injury.

Model: Diffuse axonal injury model

Early treatment 5 min after injury inhibited the unfolded protein response and cell apoptosis and relieved anxiety disorder. Delayed treatment from 14 days post-injury restored endoplasmic reticulum stress and unfolded protein response gene expression but did not improve the psychiatric phenotype.

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