Precious cargo: Modulation of the mesenteric lymph exosome payload after hemorrhagic shock.
RatHaemorrhage/shockControlledSprague-DawleyMalen = Three animals per group across three groups (total 9); prot…Direct electrical stimulation of the vagus nerveSquare-wave generator at 5 V, frequency 5 HzDuring the last 10 min of the 60 min haemorrhagic shock period, before resuscit…
Model: Trauma and haemorrhagic shock: laparotomy with femoral artery, jugular vein and mesenteric lymphatic duct cannulation, blood withdrawn until mean arterial pressure fell to 35 +/- 5 mmHg and maintained for 60 min, then resuscitation with shed blood plus twice the shed blood volume in normal saline
Trauma and haemorrhagic shock significantly increased 35 exosomal proteins post-shock with none decreased. With vagus nerve stimulation only one protein (GAPDH, 17-fold, p < 0.01) was significantly increased. Post-shock exosomes increased monocyte NF-kappaB activity whereas post-shock exosomes from…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.