Inhibition of early response genes prevents changes in global joint metabolomic profiles in mouse post-traumatic osteoarthritis.
MouseOtherC57BL/6Malen = 18 mice total, 6 per condition (uninjured, injured, injured…Intraperitoneal injection7.5 mg/kg in salineImmediately after injury, before waking from anaesthesia
Model: Non-invasive tibial compression anterior cruciate ligament rupture of the right knee: single mechanical load applied to the ankle at 1 mm/s to 12 N causing anterior tibial translation and ACL failure, completed in under 2 seconds
Injury upregulated 132 and downregulated 131 metabolites relative to contralateral uninjured joints. Flavopiridol-treated injured joints clustered more closely with uninjured control joints than with untreated injured joints, and abrogated injury-induced increases in vitamin D3, phylloquinone and a…
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