Flavopiridol With Cytarabine and Mitoxantrone for Relapsed/Refractory Acute Leukaemias
Adult Acute Myeloid Leukemia · Recurrent Adult Acute Lymphoblastic Leukemia
Enrolment: 35 · Results not recorded
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Drug · Pan cyclin-dependent kinase inhibitor (CDK1/2/4/6/9; INHIBITOR)
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Adult Acute Myeloid Leukemia · Recurrent Adult Acute Lymphoblastic Leukemia
Enrolment: 35 · Results not recorded
Esophageal Cancer
Enrolment not recorded · Results not recorded
Kidney Cancer
Enrolment not recorded · Results not recorded
B-cell Chronic Lymphocytic Leukemia · Small Lymphocytic Lymphoma
Enrolment: 52 · Results not recorded
Haematopoietic/Lymphoid Cancer · Solid Tumour
Enrolment: 100 · Results not recorded
Chronic Lymphocytic Leukemia
Enrolment: 39 · Results not recorded
B-cell Chronic Lymphocytic Leukemia · Mantle Cell Lymphoma
Enrolment: 37 · Results not recorded
Adult Solid Tumour
Enrolment: 58 · Results not recorded
Breast Cancer · Melanoma · Prostate Cancer
Enrolment: 48 · Results not recorded
Chronic Lymphocytic Leukemia
Enrolment: 9 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Non-invasive tibial compression anterior cruciate ligament rupture of the right knee: single mechanical load applied to the ankle at 1 mm/s to 12 N causing anterior tibial translation and ACL failure, completed in under 2 seconds
Injury upregulated 132 and downregulated 131 metabolites relative to contralateral uninjured joints. Flavopiridol-treated injured joints clustered more closely with uninjured control joints than with untreated injured joints, and abrogated injury-induced increases in vitamin D3, phylloquinone and a…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.