The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats.
RatOtherLewisMalen = 48 rats; 12 shoulders per group across 8 interventionsLocal application to the repair site within a hydrogel carrierImmediately at repair for acute tears; 8 weeks after tendon transection for chr…
Model: Bilateral transection of the supraspinatus and infraspinatus tendons with intramuscular botulinum toxin A injection, producing acute tears (immediate intervention) or chronic tears (intervention 8 weeks later)
Chronic tears showed greater bone loss and poorer structural properties than acute tears. Bone mineral density of the proximal humerus was higher after repair of chronic tears augmented with fibrin plus adipose-derived stem cells or gelatin methacrylate plus adipose-derived stem cells than in unrep…
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