THERAPY DOSSIER · th-9606b742643e

Adipose-derived stem cells delivered in fibrin or gelatin methacrylate hydrogel, with or without transforming growth factor-beta3

Biologic · Adipose-derived stem cells in fibrin or GelMA hydrogel +/- TGF-beta3; cell-biomaterial construct.

Evidence & regulatory context

Mechanism: Adipose-derived stem cells in fibrin or GelMA hydrogel +/- TGF-beta3; cell-biomaterial construct.
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30527883 ↗2018Mixed findings

The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats.

RatOtherLewisMalen = 48 rats; 12 shoulders per group across 8 interventionsLocal application to the repair site within a hydrogel carrierImmediately at repair for acute tears; 8 weeks after tendon transection for chr…

Model: Bilateral transection of the supraspinatus and infraspinatus tendons with intramuscular botulinum toxin A injection, producing acute tears (immediate intervention) or chronic tears (intervention 8 weeks later)

Chronic tears showed greater bone loss and poorer structural properties than acute tears. Bone mineral density of the proximal humerus was higher after repair of chronic tears augmented with fibrin plus adipose-derived stem cells or gelatin methacrylate plus adipose-derived stem cells than in unrep…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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