Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein.
MouseChemical/toxinBALB/cMalen = 58 mice in total: saline n=6; acute pancreatitis n=9; octre…IntraperitonealDiclofenac sodium 15 mg per kg; octreotide 250 micrograms p…1 hour after the first caerulein injection
Model: Caerulein 50 micrograms per kg in 50 microlitres of 0.9 percent NaCl injected intraperitoneally seven times at 1 hour intervals under ketamine and xylazine anaesthesia; animals fasted 12 hours beforehand and killed 6 hours after the last injection
Diclofenac sodium alone significantly reduced lung oedema, congestion and mononuclear inflammation, but kidney improvements were not significant and combination with octreotide significantly increased gastric neutrophil inflammation.
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