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← Studies/PMID 30482901
PRECLINICAL PUBLICATION · 2018

Rapid and robust restoration of breathing long after spinal cord injury.

Rat / Spinal cord injury

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PMID 30482901 ↗2018Mixed findings

Rapid and robust restoration of breathing long after spinal cord injury.

RatSpinal cord injuryHemisection / partialSprague-DawleyFemalen = Group sizes reported only in supplementary material; 6 spin…Intraspinal injection into the ipsilateral C4 phrenic motor pool, 1.1 mm left of midline and 1.6 mm ventral to the dorsal surface; intermittent hypoxia by inhalation chamberChondroitinase ABC 20 units per mL, 250 nL injected into th…Treatment started 12 weeks after hemisection, with a separate cohort treated 1.…

Model: Left lateral C2 spinal cord hemisection caudal to the C2 dorsal roots after C2/C3 laminectomy, the incision made to the ventral lamina surface and repeated five times from midline to the most lateral extent of the cord under ketamine and xylazine (70 mg per kg and 7 mg per kg intraperitoneally); the lesion encompassed 51.2 percent of total cord volume at the epicentre

A single chondroitinase ABC injection restored synchronised ipsilateral hemidiaphragm activity in about two thirds of chronically injured rats and improved neuromuscular junction anatomy and ventilatory responses, while combination with intermittent hypoxia strengthened ventilation but caused aberr…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.