Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Spinal cord injury
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatSpinal cord injuryHemisection / partialSprague-DawleyFemalen = Group sizes reported only in supplementary material; 6 spin…Intraspinal injection into the ipsilateral C4 phrenic motor pool, 1.1 mm left of midline and 1.6 mm ventral to the dorsal surface; intermittent hypoxia by inhalation chamberChondroitinase ABC 20 units per mL, 250 nL injected into th…Treatment started 12 weeks after hemisection, with a separate cohort treated 1.…
Model: Left lateral C2 spinal cord hemisection caudal to the C2 dorsal roots after C2/C3 laminectomy, the incision made to the ventral lamina surface and repeated five times from midline to the most lateral extent of the cord under ketamine and xylazine (70 mg per kg and 7 mg per kg intraperitoneally); the lesion encompassed 51.2 percent of total cord volume at the epicentre
A single chondroitinase ABC injection restored synchronised ipsilateral hemidiaphragm activity in about two thirds of chronically injured rats and improved neuromuscular junction anatomy and ventilatory responses, while combination with intermittent hypoxia strengthened ventilation but caused aberr…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
