Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis.
MouseChemical/toxinC57BL/6Malen = 164 mice in vivo in total: dose-ranging study 48 mice (n=6…IntraperitonealDose-ranging 5, 20 and 50 mg per kg; main studies used 50 m…Pre-treatment at 2, 24 and 48 hours before carbon tetrachloride administration
Model: Carbon tetrachloride-induced acute liver injury by intraperitoneal injection of 0.3 percent carbon tetrachloride at 10 mL per kg in olive oil (sub-lethal), with a separate lethality study using 2.5 percent carbon tetrachloride at 10 mL per kg
Chloroquine pre-treatment at 50 mg per kg lowered serum transaminases and histological injury scores at all time points, reduced hepatic and serum HMGB1, tumour necrosis factor alpha and interleukin-6, and raised 24 hour survival after lethal carbon tetrachloride from 40 to 80 percent.
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