Dexmedetomidine Attenuates Acute Lung Injury Induced by Heatstroke and Improve Outcome.
MouseOtherC57BL/6MaleIntraperitonealInjected immediately after heat exposure
Model: Heatstroke induced by exposure to ambient temperature of 39.5 plus or minus 0.2 degrees Celsius until core temperature reached 43 degrees Celsius
Dexmedetomidine significantly inhibited heatstroke-induced lung injury, improved respiratory dysfunction and the 72 hour cumulative survival rate, and suppressed TLR4/MyD88/nuclear factor kappa B signalling while restoring caveolin-1 expression.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.