Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats.
RatSpinal cord injuryUnspecifiedSprague-Dawley
Model: Acute spinal cord injury with parallel in vitro lipopolysaccharide and ATP-induced BV-2 microglial activation; injury induction protocol not stated in the abstract
Celastrol improved hindlimb motor recovery, reduced cavity area and neuronal loss, suppressed microglial activation and pyroptosis-related proteins, lowered pro-inflammatory cytokines and increased interleukin-10.
Extraction: extract · Supplied extraction confidence: 0.45. Machine-extracted fields require source verification.