A Sub-Chronic Evaluation of the Safety of Celastrol in Human Subjects
Safety
Enrolment: 35 · Results not recorded
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Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Safety
Enrolment: 35 · Results not recorded
Safety Issues
Enrolment: 5 · Results not recorded
Dandruff · Seborrhoeic Dermatitis of the Scalp
Enrolment: 23 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Acute spinal cord injury with parallel in vitro lipopolysaccharide and ATP-induced BV-2 microglial activation; injury induction protocol not stated in the abstract
Celastrol improved hindlimb motor recovery, reduced cavity area and neuronal loss, suppressed microglial activation and pyroptosis-related proteins, lowered pro-inflammatory cytokines and increased interleukin-10.
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Model: Kainate-induced excitotoxic injury of isolated neonatal rat spinal cord in vitro, monitored up to 24 h
Celastrol at 0.75 microM was not toxic to the neonatal rat spinal cord and enhanced motoneuron HSP70 expression. Applied before or after kainate it significantly reduced the number of dead motoneurons and strongly inhibited nuclear localisation of apoptosis-inducing factor. Functional protection wa…
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Model: Plantar surgical incision of the hind paw
Celastrol partially reversed incision-induced pain behaviour, reduced proinflammatory cytokine mRNA and p-p65 and p65 levels, and increased SARM and IkBalpha expression. Knockdown of SARM by shRNA partially abolished these protective effects.
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Model: Modified middle cerebral artery occlusion producing permanent focal ischaemia using a monofilament nylon suture of 0.24 to 0.26 mm diameter advanced into the internal carotid artery, with sham surgery lacking filament insertion
Celastrol reduced infarct volume from about 40% to about 20%, reduced neuronal apoptosis, improved rotarod and adhesive removal performance, and raised IL-33 and IL-10 while lowering IL-1beta, IL-6 and TNF-alpha relative to occlusion alone.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.