Caffeine attenuates brain injury but increases mortality induced by high-intensity blast wave exposure.
MouseTBIBlast / overpressureC57BL/6MaleChronic pre-injury intake, acute treatment, and pre-injury withdrawal paradigms
Model: Severe whole body blast injury from a high-intensity blast wave
Chronic caffeine alleviated blast-induced traumatic brain injury, but both chronic and acute caffeine worsened blast-induced lung injury and increased cumulative and time-segmented mortality, whereas withdrawing caffeine before injury gave mortality and lung outcomes similar to water-treated mice w…
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