The effect of aerosolized indomethacin on lung inflammation and injury in a rat model of blunt chest trauma.
RatOtherSprague-DawleyIntratracheal, aerosolised via catheter1 mg/kg15 min after blunt chest trauma
Model: Blunt chest trauma by free-dropping a hollow 200 g metal weight from 25.5, 38.3 or 51.2 cm onto the right thorax under anaesthesia after tracheotomy
Indomethacin reduced bronchoalveolar lavage total protein (1.06 plus or minus 0.39 versus 3.75 plus or minus 1.95 mg/mL, p = 0.006), alveolar FD-70 leak (0.23 plus or minus 0.19 versus 0.53 plus or minus 0.19 micrograms/mL, p = 0.02) and percentage polymorphonuclear leukocytes (13.33 plus or minus…
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