Alcohol Binge Reduces Systemic Leukocyte Activation and Pulmonary PMN Infiltration After Blunt Chest Trauma and Hemorrhagic Shock.
RatHaemorrhage/shockUnspecifiedLewisFemalen = 24 female Lewis rats in totalOral gavage5 g/kg, 30 per cent solution2 h before trauma
Model: Blunt chest (thoracic) trauma followed by 60 min haemorrhagic shock and resuscitation; sham animals underwent surgical procedures only
Ethanol significantly reduced trauma-induced IL-6, pulmonary polymorphonuclear leukocyte infiltration, lavage protein concentration, systemic leukocyte activation and monocyte inflammasome activation, but histological morphology changes after trauma were unaltered and neutrophil apoptosis was furth…
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.