Anti-High Mobility Group Box 1 Antibody Therapy May Prevent Cognitive Dysfunction After Traumatic Brain Injury.
RatTBIFluid percussionWistarMaleIntravenousAfter traumatic brain injury
Model: Traumatic brain injury induced by fluid percussion
Anti-HMGB1 monoclonal antibody attenuated activated microglial accumulation in the ipsilateral cortex, prevented ipsilateral hippocampal neuronal death, inhibited HMGB1 translocation and preserved motor and cognitive function and electroencephalography activity for 14 days after injury.
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