Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- TBI · Other · Crush
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 3
3 studies reported at therapy level; 3 evidence entries itemised.
RatTBIFluid percussionWistarMaleIntravenousAfter traumatic brain injury
Model: Traumatic brain injury induced by fluid percussion
Anti-HMGB1 monoclonal antibody attenuated activated microglial accumulation in the ipsilateral cortex, prevented ipsilateral hippocampal neuronal death, inhibited HMGB1 translocation and preserved motor and cognitive function and electroencephalography activity for 14 days after injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
RatOtherWistarMalePretreatment, before exposure to heat stress
Model: Heatstroke induced by exposure to a high-temperature and high-humidity environment, with liver injury as the target organ
HMGB1 was elevated in plasma and liver cytoplasm of heatstroke rats alongside raised transaminases. Pretreatment with anti-HMGB1 monoclonal antibody alleviated hepatic histopathological damage, lowered plasma alanine and aspartate aminotransferase, and significantly suppressed tumour necrosis facto…
Extraction: extract · Supplied extraction confidence: 0.58. Machine-extracted fields require source verification.
RatCrushLimb / muscle crushWistarMalen = n=20 per group for survival; n=6-9 per group for other endp…IntravenousAfter release of compression
Model: Bilateral hindlimb compression for 6 h followed by release (crush injury)
Anti-HMGB1 antibody improved survival, suppressed serum HMGB1, interleukin-6 and tumour necrosis factor alpha, and reduced lung damage and RAGE expression.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
