MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management.
RatWoundn = Between 3 and 6 independent experiments; per-group animal n…Topical to the wound bed for 10 min, then gauze soaked with the compound under the dressing500 microlitres of 5 micromolar MnTE-2-PyP in PBS per appli…Applied immediately after wound creation
Model: Full-thickness dorsal wounds under isoflurane: 2 cm by 2 cm in the negative pressure wound therapy arm and 1.5 cm by 1.5 cm created with a surgical blade in the MnTE-2-PyP arm; human arm used surgically debrided acute trauma wounds dressed with negative pressure wound therapy
Negative pressure wound therapy maintained antioxidant capacity and raised SOD2 protein and activity in rat and patient wound tissue, and topical MnTE-2-PyP accelerated epithelialisation and wound closure (ET25 3.904 versus 5.587 days; significant at days 4, 6 and 8), although ET80, total wound are…
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