THERAPY DOSSIER · th-875ef9b092ab

MnTE-2-PyP (MnE, BMX-010, AEOl10113), with negative pressure wound therapy as the comparator modality

Drug · MnTE-2-PyP (BMX-010), a manganese-porphyrin catalytic antioxidant/SOD mimetic; not returned by ChEMBL name search.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: MnTE-2-PyP (BMX-010), a manganese-porphyrin catalytic antioxidant/SOD mimetic; not returned by ChEMBL name search.
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02457858 ↗PHASE1completed

Manganese Porphyrin MnTE-2-PyP (BMX-010) Preservation of Islet Cell Mass for Clinical Islet Transplantation

Type 1 Diabetes

Enrolment: 5 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30390545 ↗2018Reported benefit

MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management.

RatWoundn = Between 3 and 6 independent experiments; per-group animal n…Topical to the wound bed for 10 min, then gauze soaked with the compound under the dressing500 microlitres of 5 micromolar MnTE-2-PyP in PBS per appli…Applied immediately after wound creation

Model: Full-thickness dorsal wounds under isoflurane: 2 cm by 2 cm in the negative pressure wound therapy arm and 1.5 cm by 1.5 cm created with a surgical blade in the MnTE-2-PyP arm; human arm used surgically debrided acute trauma wounds dressed with negative pressure wound therapy

Negative pressure wound therapy maintained antioxidant capacity and raised SOD2 protein and activity in rat and patient wound tissue, and topical MnTE-2-PyP accelerated epithelialisation and wound closure (ET25 3.904 versus 5.587 days; significant at days 4, 6 and 8), although ET80, total wound are…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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