Beta-2 Adrenergic and Glucocorticoid Receptor Agonists Modulate Ozone-Induced Pulmonary Protein Leakage and Inflammation in Healthy and Adrenalectomized Rats.
RatChemical/toxinWistar KyotoMaleClenbuterol intraperitoneal; dexamethasone subcutaneousClenbuterol 0.2 mg/kg plus dexamethasone 2 mg/kgFor 1 day before exposure and immediately prior to each day of air or ozone exp…
Model: Acute ozone inhalation lung injury (0.8 ppm, 4 h/day for 1 or 2 days) in sham-operated or adrenalectomised rats
Adrenalectomy reduced ozone-induced increases in BALF protein, macrophage activation, neutrophils and lung cytokine expression. Combined clenbuterol and dexamethasone reversed this protection and exacerbated most ozone-induced lung effects while diminishing circulating lymphocytes. In air-exposed s…
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