Trial title not recorded
Amyotrophic Lateral Sclerosis
Enrolment: 25 · Results not recorded
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Drug · Clenbuterol is a moderately selective beta-2 adrenergic receptor agonist (ChEMBL mec_id 6678); receptor activation raises cAMP and PKA signalling, relaxing airway smooth muscle and driving skeletal-muscle anabolic, anti-inflammatory and neurotrophic effects. The atlas entry is a two-agent combination: the dexamethasone component is a glucocorticoid receptor agonist and was NOT separately resolved in this run, so all ChEMBL fields refer to clenbuterol only. ATC R03AC14, R03CC13.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Amyotrophic Lateral Sclerosis
Enrolment: 25 · Results not recorded
Type 2 Diabetes
Enrolment: 14 · Results not recorded
Pompe Disease
Enrolment: 17 · Results not recorded
Muscle Hypertrophy in Healthy Young Men
Enrolment: 72 · Results not recorded
Skeletal Muscle Physiology
Enrolment: 60 · Results not recorded
Healthy
Enrolment: 16 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Acute ozone inhalation lung injury (0.8 ppm, 4 h/day for 1 or 2 days) in sham-operated or adrenalectomised rats
Adrenalectomy reduced ozone-induced increases in BALF protein, macrophage activation, neutrophils and lung cytokine expression. Combined clenbuterol and dexamethasone reversed this protection and exacerbated most ozone-induced lung effects while diminishing circulating lymphocytes. In air-exposed s…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Acute brain injury induced by stereotactic intra-striatal administration of IL-1beta (100 ng)
Clenbuterol attenuated all IL-1beta-induced changes in the striatum, including MBS-2 immunoreactivity and TUNEL-positive staining, and also reduced IL-1beta-induced hepatic TNF-alpha expression and the rise in circulating CINC-1, indicating suppression of both central and peripheral inflammatory re…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.