The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMale and femalen = n=4 per group pharmacokinetic cohort; n=6 for bolus plus in…Intraperitoneal loading bolus (intraperitoneal versus intravenous compared initially) with subcutaneous osmotic pump infusion5 mg/kg loading bolus, with a second 5 mg/kg bolus at 60 mi…Initiated at return of spontaneous circulation after 9 min asphyxial cardiac ar…
Model: 9 min asphyxial cardiac arrest with resuscitation (paediatric model of global cerebral ischaemia and cytotoxic oedema)
AER-271 prevented the acute rise in brain water at 3 h after cardiac arrest, reducing oedema at that time point by 82.1 per cent and returning brain water nearly to naive values. Treated rats had a 20 per cent lower neurologic deficit score at 3 h, although no significant injury effect remained at…
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