Phase 1 double-blind randomised placebo-controlled study of single and multiple ascending doses of AER-271 in healthy subjects
Stroke · Stroke, Acute · Stroke, Ischemic
Enrolment: 80 · Results not recorded
Loading the evidence…
Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Stroke · Stroke, Acute · Stroke, Ischemic
Enrolment: 80 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: 9 min asphyxial cardiac arrest with resuscitation (paediatric model of global cerebral ischaemia and cytotoxic oedema)
AER-271 prevented the acute rise in brain water at 3 h after cardiac arrest, reducing oedema at that time point by 82.1 per cent and returning brain water nearly to naive values. Treated rats had a 20 per cent lower neurologic deficit score at 3 h, although no significant injury effect remained at…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.