Pharmacological induction of Heat Shock Protein 70 by celastrol protects motoneurons from excitotoxicity in rat spinal cord in vitro.
RatSpinal cord injuryUnspecifiedWistarMale and femaleBath application to the in vitro spinal cord preparation0.75 microMApplied either before or after kainate
Model: Kainate-induced excitotoxic injury of isolated neonatal rat spinal cord in vitro, monitored up to 24 h
Celastrol at 0.75 microM was not toxic to the neonatal rat spinal cord and enhanced motoneuron HSP70 expression. Applied before or after kainate it significantly reduced the number of dead motoneurons and strongly inhibited nuclear localisation of apoptosis-inducing factor. Functional protection wa…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.