The Small Molecule NLRP3 Inflammasome Inhibitor MCC950 Does Not Alter Wound Healing in Obese Mice.
MouseWoundC57Bl/6J and Ob/Ob (on a C57Bl/6J background)Male and femalen = 5 control versus 5 treated mice per group per time point, f…Topical (pluronic gel) and oral (drinking water)Topical 1 mg per dose per day in 30% F-127 pluronic gel; or…Topical treatment daily from day 0 to day 4 after wounding
Model: Full-thickness excisional skin wounds (acute wounds in C57Bl/6J mice and impaired healing wounds in obese Ob/Ob mice)
Topical MCC950 produced no significant difference in wound surface compared with gel alone in C57Bl/6J mice and significantly impaired macroscopic wound closure in obese Ob/Ob mice, while re-epithelialisation at day 5 was unchanged. Macrophage numbers and M1 and M2 polarisation in Ob/Ob wounds were…
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