Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Wound · Burn
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Preclinical/no trial
- ChEMBL max phase
- Not recorded
- Synonyms
- MCC950; MCC-950; CP-456773; CRID3; MCC950 (sodium)
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseWoundC57Bl/6J and Ob/Ob (on a C57Bl/6J background)Male and femalen = 5 control versus 5 treated mice per group per time point, f…Topical (pluronic gel) and oral (drinking water)Topical 1 mg per dose per day in 30% F-127 pluronic gel; or…Topical treatment daily from day 0 to day 4 after wounding
Model: Full-thickness excisional skin wounds (acute wounds in C57Bl/6J mice and impaired healing wounds in obese Ob/Ob mice)
Topical MCC950 produced no significant difference in wound surface compared with gel alone in C57Bl/6J mice and significantly impaired macroscopic wound closure in obese Ob/Ob mice, while re-epithelialisation at day 5 was unchanged. Macrophage numbers and M1 and M2 polarisation in Ob/Ob wounds were…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
MouseBurnContact / flameNlrp3-deficient, caspase-1-deficient (Ice) and wild-type miceMale
Model: Superficial burn to the plantar surface of the left hind paw using a hot plate at 52.5 degrees C for 25 s
Burn-induced mechanical and thermal allodynia developed normally in Nlrp3-deficient and caspase-1-deficient mice and in mice given MCC950. Oedema was reduced only in caspase-1-deficient mice, and weight bearing changes were attenuated in Nlrp3-deficient and MCC950-treated mice at 72 h only. The aut…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
