Effects of Phenelzine Administration on Mitochondrial Function, Calcium Handling, and Cytoskeletal Degradation after Experimental Traumatic Brain Injury.
RatTBIControlled cortical impactSprague-DawleyMaleSubcutaneous10 mg/kg then 5 mg/kg15 min and 12 h post-injury; delayed window study used 1 h and 24 h post-injury
Model: Severe controlled cortical impact (2.2 mm depth)
Phenelzine significantly improved mitochondrial respiration at 24 and 72 h, improved calcium buffering capacity and membrane potential at 24 h, and reduced alpha-spectrin breakdown at 24 h but not 72 h. Attenuation of aldehyde accumulation did not reach significance. Delayed administration retained…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.