Nicotine impairs intra-substance tendon healing after full thickness injury in a rat model.
RatOtherSprague-DawleyMalen = 60 rats total, 30 per group; n = 5 per group per time point…Subcutaneous osmotic pump (Alzet 2ML4)61 mg/mL nicotine solution delivered at 2.5 microlitres per…Started 3 months before tendon transection and continued until euthanasia
Model: Blunt full-thickness transection of the left Achilles tendon with one week of plantarflexion casting
Nicotine impaired tendon healing. It slowed vascular inflow (increased rise time and reduced wash-in rate at 21 and 42 days), reduced vessel density at the injury site, altered gait (reduced braking force, rate of loading, stride width and speed) and increased passive ankle range of motion with red…
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