Rescue from lethal acute radiation syndrome (ARS) with severe weight loss by secretome of intramuscularly injected human placental stromal cells.
MouseRadiationC3H/HeNHsd irradiated mice; BALB/c bone marrow donors for the in vitro migration assayMalen = Four to five mice sacrificed per group at each of days 0, 2…Intramuscular, into the right and left lateral and cranial thigh muscles using 27G needles2 x 10^6 viable cells per injection in 0.1 mL, 50 uL per li…First injection 1 day after 7.7 Gy irradiation
Model: Lethal acute radiation syndrome induced by 7.7 Gy whole body irradiation using a clinical 6-18 MeV linear accelerator
Two intramuscular PLX-RAD injections raised 21 day survival after 7.7 Gy from about 25 per cent to nearly 100 per cent, with faster regain of weight and haematopoietic recovery from day 9 onwards, associated with elevated circulating human cytokines.
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