THERAPY DOSSIER · th-e04020a8fdc7

PLX-RAD (PLX-R18) expanded human placental stromal cells, predominantly of fetal origin, and their secretome

Biologic · PLX-R18 (PLX-RAD) expanded human placental stromal cells and secretome; cell therapy.

Evidence & regulatory context

Mechanism: PLX-R18 (PLX-RAD) expanded human placental stromal cells and secretome; cell therapy.
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03797040 ↗PHASE1unknown

PLX-R18 for Post-Exposure Prevention or Treatment of Hematopoietic Syndrome of Acute Radiation Syndrome

Ionizing Radiation Exposure

Enrolment: 27 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30334381 ↗2018Reported benefit

Rescue from lethal acute radiation syndrome (ARS) with severe weight loss by secretome of intramuscularly injected human placental stromal cells.

MouseRadiationC3H/HeNHsd irradiated mice; BALB/c bone marrow donors for the in vitro migration assayMalen = Four to five mice sacrificed per group at each of days 0, 2…Intramuscular, into the right and left lateral and cranial thigh muscles using 27G needles2 x 10^6 viable cells per injection in 0.1 mL, 50 uL per li…First injection 1 day after 7.7 Gy irradiation

Model: Lethal acute radiation syndrome induced by 7.7 Gy whole body irradiation using a clinical 6-18 MeV linear accelerator

Two intramuscular PLX-RAD injections raised 21 day survival after 7.7 Gy from about 25 per cent to nearly 100 per cent, with faster regain of weight and haematopoietic recovery from day 9 onwards, associated with elevated circulating human cytokines.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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