LNK deficiency promotes acute aortic dissection and rupture.

LNK deficiency promotes acute aortic dissection and rupture.

Model: Angiotensin II infusion induced acute aortic dissection and rupture in Lnk (SH2B3) deficient mice, with adoptive transfer of Lnk-/- leukocytes into Rag1-/- recipients

Doxycycline prevented early aortic neutrophil accumulation and significantly reduced the incidence of aortic dissection and rupture in angiotensin II infused Lnk deficient mice, while LNK loss itself markedly increased susceptibility.

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