Hypertonic saline resuscitation protects against kidney injury induced by severe burns in rats.
RatBurnUnspecifiedSprague-DawleyFluid resuscitation (intravascular volume replacement)400 mEq/L hypertonic saline solutionAfter burn injury, as resuscitation
Model: Severe burn injury in rats with secondary acute kidney injury
Hypertonic saline reduced the renal water content ratio and improved renal histopathology relative to lactated Ringer's, with lower serum creatinine, cystatin C, TNF-alpha, IL-1beta and HMGB1, higher serum sodium and renal superoxide dismutase activity, and lower renal malondialdehyde.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.