THERAPY DOSSIER · th-72a80223f748

Hypertonic saline (400 mEq/L) fluid resuscitation

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn · Endotoxin/LPS
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 9

5 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00316004 ↗Injury indicationPHASE3terminated

Phase 3 study of hypertonic resuscitation following severe traumatic brain injury

Brain Injuries, Traumatic

Enrolment: 1331 · Results not recorded

NCT00316017 ↗Injury indicationPHASE3terminated

Phase 3 study of hypertonic resuscitation following traumatic injury with hypovolaemic shock

Shock, Traumatic

Enrolment: 895 · Results not recorded

NCT01642524 ↗Injury indicationPHASE3completed

The Toronto prehospital hypertonic resuscitation head injury and multi organ dysfunction trial

Traumatic Brain Injury

Enrolment: 114 · Results not recorded

NCT00878631 ↗Injury indicationPHASE2/PHASE3completed

The Toronto prehospital hypertonic resuscitation head injury and multi organ dysfunction trial

Brain Injuries

Enrolment: 113 · Results not recorded

NCT00113685 ↗Injury indicationNAcompleted

Effect of hypertonic resuscitation for blunt trauma

Respiratory Distress Syndrome, Adult · Head Injuries, Closed · Shock, Traumatic

Enrolment: 209 · Results not recorded

NCT03300648 ↗PHASE3completed

Treating brain swelling in paediatric cerebral malaria (hypertonic saline)

Malaria, Cerebral

Enrolment: 57 · Results not recorded

NCT01428050 ↗PHASE2unknown

Randomised controlled trial on the use of a restrictive fluid regimen with hypertonic saline for patients undergoing pancreaticoduodenectomy

Pancreaticoduodenectomy

Enrolment: 264 · Results not recorded

NCT03741257 ↗NAunknown

Hypertonic saline 3% compared to hypertonic saline 1.8% for fluid management of intestinal obstruction surgery

Intestinal Obstruction

Enrolment: 50 · Results not recorded

NCT02297659 ↗NAunknown

Use of hypertonic saline after damage control laparotomy to improve early primary fascial closure

Open Abdomen After Damage Control Laparotomy

Enrolment: 312 · Results not recorded

Preclinical evidence 2

2 studies reported at therapy level; 2 evidence entries itemised.

PMID 30327229 ↗2018Reported benefit

Hypertonic saline resuscitation protects against kidney injury induced by severe burns in rats.

RatBurnUnspecifiedSprague-DawleyFluid resuscitation (intravascular volume replacement)400 mEq/L hypertonic saline solutionAfter burn injury, as resuscitation

Model: Severe burn injury in rats with secondary acute kidney injury

Hypertonic saline reduced the renal water content ratio and improved renal histopathology relative to lactated Ringer's, with lower serum creatinine, cystatin C, TNF-alpha, IL-1beta and HMGB1, higher serum sodium and renal superoxide dismutase activity, and lower renal malondialdehyde.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

PMID 26529650 ↗2015Mixed findings

Impact of Time on Fluid Resuscitation with Hypertonic Saline (NaCl 7.5%) in Rats with LPS-Induced Acute Lung Injury.

RatEndotoxin/LPSWistarMaleEarly versus late resuscitation, late given after the inflammatory scenario was…

Model: Bacterial lipopolysaccharide-induced acute lung injury

Late fluid resuscitation with hypertonic or normal saline did not reduce mortality and increased pulmonary inflammation, worsened pulmonary function and increased MMP-2 and MMP-9 activity and collagen deposition, unlike early treatment; the therapeutic window for benefit from hypertonic saline was…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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