Acteoside Improves Muscle Atrophy and Motor Function by Inducing New Myokine Secretion in Chronic Spinal Cord Injury.
MouseSpinal cord injuryContusionddYFemalen = Acteoside n = 8 mice, vehicle n = 8 mice, sham n = 6 mice;…Intramuscular0.1 mg per limb, injected into the right and left hindlimbsTreatment started 30 days after spinal cord injury
Model: Contusive spinal cord injury; laminectomy at T11 with a 13.5 g rod of 1 mm tip diameter dropped from 3 cm onto the exposed L1 segment, approximately 13.5 kdyn, treated in the chronic phase
Intramuscular acteoside in chronic spinal cord injured mice significantly improved Basso Mouse Scale and Toyama Mouse Score, increased gastrocnemius and tibialis anterior weights and increased caudal 5-HT axonal and presynaptic density relative to vehicle.
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