Zhenbao Pill reduces Treg cell proportion in acute spinal cord injury rats by regulating TUG1//HSP27 axis.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 35 rats in total; sham n = 7, spinal cord injury n = 7, Zhe…Oral for Zhenbao Pill; siRNA-TUG1 reported as intrathecal in one section and intraperitoneal in anotherZhenbao Pill 0.4 g/kg; siRNA-TUG1 or negative control 20 nm…Intrathecal siRNA injection immediately following spinal cord injury; Zhenbao P…
Model: Acute contusive spinal cord injury; laminectomy at T9-T11 keeping the dura undamaged, with contusion by a 2.4 mm diameter, 20 g impactor dropped from 2.5 cm onto T10
Zhenbao Pill significantly reversed the reduction in Basso, Beattie and Bresnahan score after spinal cord injury and reduced regulatory T cell proportion and Foxp3, effects abolished by TUG1 knockdown.
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