THERAPY DOSSIER · th-a14c01fed351

Zhenbao Pill, a 29 herb Chinese medicine formula, alone and combined with lentivirus packaged siRNA against TUG1

Nutraceutical · Zhenbao Pill, a 29-herb Tibetan/Mongolian medicine formula (in this study also combined with anti-TUG1 siRNA).

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Zhenbao Pill, a 29-herb Tibetan/Mongolian medicine formula (in this study also combined with anti-TUG1 siRNA).
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06049498 ↗NAcompleted

Efficacy and Safety of Mongolian Medicine ZhenBao Pills on Limb Function Recovery After Acute Ischemic Stroke

Ischemic Stroke

Enrolment: 216 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30287503 ↗2018Reported benefit

Zhenbao Pill reduces Treg cell proportion in acute spinal cord injury rats by regulating TUG1//HSP27 axis.

RatSpinal cord injuryContusionSprague-DawleyFemalen = 35 rats in total; sham n = 7, spinal cord injury n = 7, Zhe…Oral for Zhenbao Pill; siRNA-TUG1 reported as intrathecal in one section and intraperitoneal in anotherZhenbao Pill 0.4 g/kg; siRNA-TUG1 or negative control 20 nm…Intrathecal siRNA injection immediately following spinal cord injury; Zhenbao P…

Model: Acute contusive spinal cord injury; laminectomy at T9-T11 keeping the dura undamaged, with contusion by a 2.4 mm diameter, 20 g impactor dropped from 2.5 cm onto T10

Zhenbao Pill significantly reversed the reduction in Basso, Beattie and Bresnahan score after spinal cord injury and reduced regulatory T cell proportion and Foxp3, effects abolished by TUG1 knockdown.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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