Effects of Rosuvastatin on Apolipoprotein J in Balloon-Injured Carotid Artery in Rats.
RatOtherWistarMalen = Control n = 20, model n = 20, rosuvastatin intervention n =…Intragastric (oral gavage)10 mg/kg per dayRats were weighed and randomised on the day of operation and the intervention g…
Model: Carotid artery balloon injury; a 2F balloon catheter inserted into the carotid artery, inflated and withdrawn three times to denude the endothelium
Rosuvastatin limited the rise in intimal to medial ratio after balloon injury and upregulated apolipoprotein J messenger RNA and protein, which peaked earlier at 2 weeks than in the untreated model group at 3 weeks.
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