Atorvastatin versus rosuvastatin intensive statin regimens in Chinese elderly undergoing PCI
Percutaneous Coronary Intervention
Enrolment: 1000 · Results not recorded
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Drug · HMG-CoA reductase inhibitor; action type INHIBITOR, direct interaction, disease efficacy flagged (ChEMBL mec_id 1056, recorded against the calcium salt CHEMBL1744447, parent CHEMBL1496). ATC C10AA07. The meloxicam co-treatment is CHEMBL599 (approved 2000, ATC M01AC06, black box warning).
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Percutaneous Coronary Intervention
Enrolment: 1000 · Results not recorded
Type 2 Diabetes · Hypertriglyceridemia
Enrolment: 68 · Results not recorded
Dyslipidemias
Enrolment: 10000 · Results not recorded
Diabetes
Enrolment: 160 · Results not recorded
Hypercholesterolemia
Enrolment: 4875 · Results not recorded
Hypertension · Hypercholesterolemia
Enrolment: 219 · Results not recorded
Mixed Dyslipidemias
Enrolment: 362 · Results not recorded
ANCA-associated Vasculitis
Enrolment: 121 · Results not recorded
Chronic Periodontitis · Type 2 Diabetes
Enrolment: 80 · Results not recorded
Platelet Dysfunction
Enrolment: 146 · Results not recorded
Endometrial Carcinoma Stage I
Enrolment: 48 · Results not recorded
Atherosclerotic Cardiovascular Disease
Enrolment: 144 · Results not recorded
Healthy
Enrolment: 26 · Results not recorded
Hypercholesterolaemia
Enrolment: 60 · Results not recorded
CYP2C19 Metabolizers
Enrolment: 50 · Results not recorded
Diabetes Mellitus
Enrolment: 36 · Results not recorded
Healthy
Enrolment: 45 · Results not recorded
Healthy
Enrolment: 59 · Results not recorded
Hyperlipidemias · Hypertension
Enrolment: 2845 · Results not recorded
Ischemic Stroke · TIA
Enrolment: 300 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Blunt chest injury producing lung contusion in rats
Rosuvastatin significantly decreased cytokine levels raised by blunt chest trauma and increased iNOS, COX-2, haem oxygenase-1 and prostaglandin E2 in bronchoalveolar lavage fluid. Co-administration of meloxicam prevented these changes, indicating that the prostaglandin pathway mediates the statin e…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Acute myocardial infarction induced by ligation of the left anterior descending coronary artery
Infarcted rats showed reduced LVEF, fractional shortening and cardiac output with raised ventricular volumes, heart rate and cardiac injury markers, together with down-regulated miR-126 and up-regulated VEGF-A. miR-126 was confirmed to target the VEGF-A 3' UTR by luciferase reporter assay. The auth…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: murine controlled cortical impact traumatic brain injury and a murine intracerebral haemorrhage model
Rosuvastatin 1 mg/kg gave the greatest functional improvement after traumatic brain injury with less neuronal degeneration, reduced microgliosis and preserved CA3 neuronal density, while simvastatin 1 mg/kg was most effective after intracerebral haemorrhage independently of haemorrhage volume.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Carotid artery balloon injury; a 2F balloon catheter inserted into the carotid artery, inflated and withdrawn three times to denude the endothelium
Rosuvastatin limited the rise in intimal to medial ratio after balloon injury and upregulated apolipoprotein J messenger RNA and protein, which peaked earlier at 2 weeks than in the untreated model group at 3 weeks.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.