Internal decompression of the acutely contused spinal cord: Differential effects of irrigation only versus biodegradable scaffold implantation.
MixedSpinal cord injuryContusionSprague-Dawley ratsFemale ratsIntraspinal implantation after pial opening and irrigationA single sized scaffold implanted into the decompression ca…Rats implanted acutely after contusion; minipigs implanted at 4, 6 and 24 h aft…
Model: Thoracic contusion spinal cord injury in rats and T10 contusion in Gottingen minipigs, followed by internal decompression comprising pial opening, extrusion of necrotic debris and irrigation
Internal decompression alone reduced inflammatory activity and cavity volume and increased tissue sparing, and scaffold implantation further reduced cavitation and increased Schwann cell recruitment, but no group differed significantly in open field locomotion despite a correlation between spared e…
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