THERAPY DOSSIER · th-f8e8f60a3150

PLGA-PLL biodegradable scaffold implanted after internal decompression

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03762655 ↗Injury indicationNAterminated

Neuro-Spinal Scaffold for Safety and Neurologic Recovery in Complete Thoracic AIS A Spinal Cord Injury (INSPIRE 2.0)

Injury, Spinal Cord

Enrolment: 20 · Results not recorded

NCT00836797 ↗Phase not recordedcompleted

Phase I Radiographic Assessment of Bone Regeneration in Alveolar Sockets With PLGA Bioscaffold

Alveolar bone preservation

Enrolment: 33 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30265898 ↗2018Mixed findings

Internal decompression of the acutely contused spinal cord: Differential effects of irrigation only versus biodegradable scaffold implantation.

MixedSpinal cord injuryContusionSprague-Dawley ratsFemale ratsIntraspinal implantation after pial opening and irrigationA single sized scaffold implanted into the decompression ca…Rats implanted acutely after contusion; minipigs implanted at 4, 6 and 24 h aft…

Model: Thoracic contusion spinal cord injury in rats and T10 contusion in Gottingen minipigs, followed by internal decompression comprising pial opening, extrusion of necrotic debris and irrigation

Internal decompression alone reduced inflammatory activity and cavity volume and increased tissue sparing, and scaffold implantation further reduced cavitation and increased Schwann cell recruitment, but no group differed significantly in open field locomotion despite a correlation between spared e…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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