NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice.
MouseChemical/toxin
Model: Acute binge ethanol exposure causing hepatic and pancreatic injury, in Nrf2-knockout and wildtype mice
Nrf2-knockout mice showed exaggerated hypoglycaemia and hypothermia, increased mortality and worse hepatic and pancreatic injury after binge ethanol. The clinically used NRF2 activator dimethyl fumarate protected against ethanol-induced hypoglycaemia and lethality
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